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Here to help in the fight against prostate cancer

Prostate cancer mortality has declined by approximately 50% since 1993 because of improvements in detection and treatment. However, prostate cancer remains a key challenge in men’s health as a new patient is diagnosed every 2 minutes, and it remains the second-leading cause of cancer death in American men.1 Quest Diagnostics remains committed to providing a comprehensive menu of testing offerings, from screening to survivorship, to support patients and their physicians.

Screening

Guideline Based Hereditary Cancer Panel

The Guideline Based Hereditary Cancer Panel includes 32 genes associated with a broad spectrum of hereditary cancers. This can include, but is not limited to, cancers of the prostate, colon, endometrium, stomach, urinary tract, ovary, pancreas, breast, rectum, and other tissues. Individuals with a positive result (pathogenic or likely pathogenic variant detected) have an increased risk for developing certain cancers relative to that of the general population.

Prostate Specific Antigen (PSA)

Quest Diagnostics offers a full range of PSA tests to support early detection of prostate cancer. Serial monitoring of PSA levels at regular intervals, along with physical examinations and other tests, may help to detect recurrent prostate cancer.

IsoPSA®

A more effective test to stratify patients with elevated PSA levels, IsoPSA assesses structural isoforms of PSA correlated with malignancy. IsoPSA is an accurate, simple, and proven addition to the screening tests available for prostate cancer.

Diagnosis

AmeriPath® Pathology Services

The AmeriPath® national network of board-certified pathologists provides comprehensive pathology services utilizing state-of-the-art technologies, including immunohistochemistry and molecular diagnostics.

We are an industry leader in prostate pathology expertise. Combined with our comprehensive test menu and advanced technology, our expertise ensures you receive accurate diagnostic, prognostic, and therapeutic information promptly.

Immunohistochemistry - Prostate Triple Stain

Quest Diagnostics maintains an up-to-date and robust selection of immunohistochemical stains to gather diagnostic insight for the patient, including prostate triple stain, comprising P504S, HMW Keratins, and P63.

Pathologic evaluation of prostate cancer can be challenging, especially when there is a small focus of cancer. Because benign prostate glands contain basal cells and cancerous glands do not, differential staining of basal cells in the prostate may be useful for diagnosis. This test uses a combination of several antibodies (applied to a single slide) that differentially stain for basal cells and neoplastic cells in the prostate: P504S stains prostate adenocarcinoma, whereas p63 and the high molecular weight cytokeratins stain benign prostate basal epithelial cells.

This combination may also help differentiate prostate cancer from precancerous lesions such as prostatic intraepithelial neoplasia (PIN), especially when tissue is limited.

Treatment selection

Solid Tumor Expanded Panel

Precision medicine is an emerging approach to disease prevention and treatment that takes individual variability into account. This next-generation sequencing (NGS) panel, along with the computational resources and tools that process and analyze the data, allows the characterization of individual patients and tumor types. Guidelines exist for using results from many of these genes for selection of FDA-approved therapies.

This NGS panel can accurately and sensitively sequence more target genes with less DNA, with reduced cost, time, and labor as compared with more limited sequencing methods, and the physician can become aware of alternative treatments available to the patient based on presence of mutations in other genes the physicians might not have considered. Microsatellite instability (MSI) and tumor mutation burden (TMB) are also included. The panel allows the generation of diverse data obtained and analyzed in real time, enabling enrollment in specific clinical trials and adaptation of treatment strategies.

Monitoring

Haystack MRD™

Sensitivity matters when looking for the lowest levels of disease, such as residual disease after surgery or response to adjuvant chemotherapy. Haystack MRD minimizes false negatives by detecting ultralow levels of ctDNA, providing confidence in therapeutic decisions.4

Quest is proud to support the impactful PSAonPSA campaign, raising awareness about the importance of PSA testing in prostate cancer detection and supporting donations to ZERO Prostate Cancer. By joining forces with this initiative, we are committed to promoting early screening, education, and proactive health measures. Together, we can empower individuals to prioritize their well-being and take control of their testing to improve patient outcomes. Join us in supporting the PSAonPSA campaign and making a difference in the fight against prostate cancer.
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This information is provided for informational purposes only and is not intended as medical advice. A physician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.

 

References

1.      American Cancer Society. Key Statistics for Prostate Cancer. Accessed August 5, 2025. Key Statistics for Prostate Cancer | Prostate Cancer Facts | American Cancer Society

2.      Klein, et al. Urol Oncol. 2022;40(9):408.e9-408.e18.

3.      Benidir et al., Urology. 2023;176:115-120

4.      Data on file. Haystack Oncology; 2024.