Skip to main content

Clinical drug monitoring

At the forefront of drug monitoring

Drug misuse occurs across many segments of the population, which is why we offer a broad array of drug testing for your diverse needs. Whether you are seeking to start a drug monitoring program or to supplement an existing program with additional testing, we offer urine and oral fluid drug testing to meet the needs of healthcare providers, pain specialists, behavioral health specialists, and health systems.

Our reputation in clinical laboratory diagnostics is built on an unparalleled commitment to service, coupled with our industry-leading, comprehensive drug testing portfolio. This includes an extensive menu for prescription drugs used in the treatment of anxiety, depression, and substance use disorders; for other controlled medications; and for substances of abuse.

With state-of-the-art technologies, fast turnaround times, easy-to-interpret results, and more than 700 on-staff toxicology and medical experts, Quest Diagnostics helps you protect your patients and your practice by helping you make more informed decisions.

Insights, clinical benefits, patient compliance, and protection

Explore our provider-focused clinical drug monitoring information for primary care, pain specialists, behavioral health specialists, and health systems.

Provider information

Prescription drug monitoring: Why monitor your patients?

We recognize that behind every specimen and result there is a human life—a life whose quality may be improved when pain or other controlled medications are used as you prescribed. For example, for responsible patients with refractory chronic and recurring pain, opioids not only relieve suffering, but also can support normal daily functioning, alleviate stress, and improve sleep.

Periodic urine drug testing (UDT) or oral fluid drug testing can help you to:

  • Monitor your patient treatment plan
  • Detect other nonprescribed medication(s)
  • Manage therapy safety and maintain availability for your patients by assisting with regulatory compliance
  • Test for other drugs of abuse (cocaine, methamphetamine, etc)

Controlled substance medications have been linked to diversion (passing the drug on to others for sale or use), noncompliance, and abuse. 

If you oversee patients who take pain or other controlled medications, especially those whom you suspect may be abusing these substances, how can you meet state and federal regulations yet still provide access to needed therapies?

One step you can take is proactive drug monitoring with urine drug testing (UDT) or oral fluid drug testing, which helps to:

  • Supplement patient self-reporting and usage of state Prescription Drug Monitoring Program (PDMP) information, with documented lab results
  • Identify drug compliance, diversion, or abuse

Quest Diagnostics constantly seeks innovative ways to enhance patient care and provide value to our customers. We provide tools that can help you create an efficient, reliable drug monitoring program. 

Novel Psychoactive Substances (NPS), also known as designer or synthetic drugs, are designed to mimic the effect of controlled substances and/or illicit drugs while circumventing national and international drug scheduling laws.1,2

Over the past decade there has been a significant increase in the use of NPS, and they have been implicated in overdose and mass-poisoning events.3,4 Often consumed unknowingly and found in combination with other substances, NPS may supplant traditional drugs of abuse and can be more potent and harder to detect with traditional testing.1,3 Two NPS drug classes in particular—other illicit additives (xylazine) and fentanyl analogs (acetyl fentanyl)—are frequently found in specimens and contribute to the nation’s misuse crisis.5

To help protect your patients, Quest Diagnostics offers definitive drug testing for major NPS classes with the Drug Monitoring, NPS panel. Developed to help address the changing drug epidemic, this panel simultaneously identifies NPS classes using definitive liquid chromatography with tandem mass spectrometry (LC-MS/MS)-based testing and reports out at the class level to help identify misuse.

Go inside the rising crisis of Novel Psychoactive Substances

Our latest Quest Diagnostics Health Trends® report found that approximately 13.1% of remnant specimens tested were positive for at least 1 Novel Psychoactive Substance (NPS),5 highlighting the importance of utilizing clinical drug monitoring to identify potential misuse or noncompliance.


Download Drug Misuse in America 2023: the Growing Crisis of Novel Psychoactive Substances (NPS) for an overview of the shifting drug crisis from misuse of prescription opioids to NPS.

download the report

Our comprehensive test menu covers a broad range of substances

We offer a broad menu of drug tests, including tests for prescription drugs, other controlled medications, and illicit drugs—with enhanced sensitivity to better detect benzodiazepines and opioids.

Drug / Drug Class

  • Alcohol metabolites (EtG, EtS)
  • Alcohol biomarkers (PEth)
  • Amphetamines
  • Amphetamines, with reflex to d-methamphetamine (dextromethamphetamine) and l-methamphetamine (levomethamphetamine) isomers
  • Antidepressants
  • Antipsychotics (urine)
  • Antipsychotics (serum)
  • Barbiturates
  • Benzodiazepines
  • Buprenorphine with naloxone
  • Carisoprodol
  • Cocaine metabolite
  • Eszopiclone
  • Fentanyl
  • Gabapentin
  • Heroin metabolite
  • Marijuana metabolite
  • Meperidine
  • Methadone metabolite
  • Methamphetamine d/l isomers
  • Methylphenidate
  • Mitragynine
  • Naltrexone
  • Opiates
  • Oxycodone
  • Phencyclidine
  • Pregabalin
  • Propoxyphene
  • Synthetic cannabinoids
  • Synthetic stimulants
  • Tapentadol
  • Tramadol
  • Tricyclic antidepressants
  • Zolpidem

We also offer a wide range of panels that screen for several different combinations of drugs and medications.


Monitoring and reporting drug use and misuse

Why monitoring is important

Aggregated drug testing surveillance data provides important and objective insights to help inform harm reduction strategies. The right data at the right time can help guide public policy and evaluate the effectiveness of prevention/intervention programs.

In-depth insights into the trends for drug positivity can support preventive actions and evaluate whether treatment programs have successfully impacted the drug misuse epidemic in their local communities.

Why work with Quest

Quest has the most extensive database of drug test results in the industry, providing insights and information on a national, regional, and local level.

States, health departments, communities, health systems, practices, and providers can work with us to monitor their statewide, regional, and local drug testing programs.

Together, we can generate meaningful surveillance data that helps drive towards positive outcomes in the battle against overdose and drug misuse disorders.



We work every day to bring you exceptional service and efficiency.

We offer a broad range of drug tests to identify the presence of prescribed, non-prescribed, and illicit drugs. We also provide other clinical testing services for conditions such as infectious disease and general health.

The power of Quest

Drug monitoring resource center

We offer a variety of useful resources for healthcare professionals.

Resource Center


1. Peacock A, Bruno R, Gisev N, et al. New psychoactive substances: challenges for drug surveillance, control, and public health responses. Lancet. 2019;394(10209):1668-1684. doi:10.1016/s0140-6736(19)32231-7

2. Mohr ALA, Logan BK, Fogarty MF, et al. Reports of adverse events associated with use of novel psychoactive substances, 2017–2020: a review. J Anal Toxicol. 2022;46(6):e116-e185. doi:10.1093/jat/bkac023

3. Iwersen-Bergmann S, Lehmann S, Heinemann A, et al. Mass poisoning with NPS: 2C-E and Bromo-DragonFly. Int J Legal Med. 2019;133(1):123-129. doi:10.1007/s00414-018-1882-9

4. The Center for Forensic Science Research & Education. Trend Reports. Accessed February 9, 2024.

5. Quest Diagnostics. Health Trends Drug misuse in America 2023: the growing crisis of novel psychoactive substances. December 23, 2024. Accessed February 12, 2024.

Our toxicology experts are here for you

Whether you want to discuss test selection, sample requirements, results interpretation, or to schedule an in-depth call for more complex questions, our team is available via phone at 1.877.40.RXTOX (1.877.407.9869)

Contact us