Skip to main content

Weather alert

Due to Hurricane Isaias, our Patient Service Centers in affected areas may be closed. We ask that patients please double check your appointment status to ensure your designated Patient Service Center is operational. For site-specific information, please use Find a location and enter your zip code.

Hide

Unlocking insights: The value of therapeutic area datasets in drug development and commercialization

Patient data fuels every stage of a drug’s development and commercialization. But pharma companies bringing different drugs to market at different times typically must purchase real-world data from different vendors on a case-by-case basis. The process is costly, inefficient, and time-consuming. What’s more, since usage parameters are spelled out in contracts, data likely can’t be shared with other internal teams, even those working in the same therapeutic area (TA).

In response, Quest Diagnostics has recently developed a suite of TA datasets that can be used across teams for a variety of use cases. Curated by medical, clinical, and biostatistical experts, the datasets include those biomarkers that are relevant to disease discovery, diagnosis, and monitoring.

Simplifying licensing

As noted above, teams typically access lab data for a single-use case. Each additional use case triggers a change order and introduces delays, since new contracts must be reviewed and approved.

"We’ve taken a different approach by offering simple enterprise licensing pricing based on field of use, whether clinical or commercial . . . Enterprise contracts cover a very broad set of use cases for an indication."
- Parag More, executive director, Healthcare Analytics Solutions - Life Sciences (clinical trials) at Quest Diagnostics

More notes that companies can attain both cost savings and operational efficiencies through enterprise pricing. In fact, Quest’s internal cost calculations show that companies could save up to 40% on their yearly data costs.

A look at Quest’s TA datasets

The TA datasets offer curated, indication-specific sets of clinical and genetic data for more than 50 diseases. All data goes through a tokenization process, so it never shows who the individual patients are.

The data is drawn from Quest’s large and growing database, which includes results from more than 378 million unique patients and from 3,500+ tests. It can also be overlapped with data from other sources, including claims, electronic health records, and prescription data, which enables a more robust patient profile.

“The richer the data pharma companies can access, the more useful it can be,” More says. “Researchers and marketers alike benefit when datasets include clinical biomarkers, genetic biomarkers, and diagnostic codes; a combination of these can help paint a more accurate picture.”

In the oncology space alone, TA datasets cover more than three dozen diseases, including breast cancer, colorectal cancer, prostate cancer, and more. Other disease states include Alzheimer’s disease, asthma, ulcerative colitis, and more.

Prostate cancer is a good example of what the TA datasets contain. Most people are familiar with the prostate-specific antigen (PSA) test, which is used both to screen men for prostate cancer and to monitor disease progression. But the PSA test is just 1 
of more than 40 tests Quest Diagnostics administers that can give insights into prostate cancer, a disease that affects 1 in 8 men during their lifetime. For example, elevated levels of alkaline phosphate (ALP) in the blood have been associated with an increased risk of mortality in patients with hormone-sensitive prostate cancer.

“These tests are included in our prostate cancer TA dataset, as are 15+ genetic markers and 2 diagnostic and ICD-10 codes,” More says. “That gives pharma companies a far more robust picture of this common disease than PSA results alone.”

Quest transforms complex genetic information into simplified categorical values. This discretization makes analysis easier.

Use cases for lab data

TA datasets can support a wide range of clinical and commercial use cases. Here are a few ways pharma companies can use the data under enterprise licensing:

  • Clinical trial feasibility and recruitment
  • Patient journey studies
  • Identification of potential prescribing physicians
  • Tailoring product launch strategies
  • Health economics and outcomes research

Companies that license TA datasets can access 2 distinct cohorts, depending on their needs:

  • Test-Based Cohort: Focuses on indication-specific diagnostic tests over the last 5 years, plus 1-year prospective; this dataset is ideal for researchers seeking to study critical biomarkers and treatment responses linked to specific tests.
  • Patient-Centric Cohort: Includes all lab encounters for patients who meet the criteria for specific therapeutic areas, offering 
a complete longitudinal record over the last 5 years, plus a 1-year prospective. This deidentified dataset allows for a comprehensive analysis of patient journeys, outcomes, and the identification of comorbidities.

“We’re excited to offer these curated datasets to pharma companies,” More says. “We’re confident that they can help those companies drive efficiency and maximize their data usage.”

Learn more about their comprehensive therapeutic area datasets.

Learn more