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Chromogranin A Testing

Test code(s) 31912, 31911

As of April 19, 2021, Quest uses a liquid chromatography-tandem mass spectrometry (LC/MS/MS)-based assay to measure chromogranin (Chromogranin A, LC/MS/MS; test code 31911). Previously, chromogranin A was measured using an enzyme-linked immunosorbent assay (ELISA).

Typically, chromogranin A levels are around 2.5 times higher with the LC/MS/MS assay—this relationship is captured by the following equation: ELISA result = 13.6 + 0.36 × LC/MS/MS result; correlation coefficient = 0.71.

Reference intervals with both methods are shown below:

A “rebaseline” test code is offered for side-by-side determination of chromogranin A levels with both the ELISA and LC/MS/MS assay until April 19, 2022: Chromogranin A, Rebaseline (test code 31912). 

Details on methods and performance of the chromogranin A by LC/MS/MS assay have been published.1

If you have further questions or concerns, please contact Quest Client Services (1.800.642.4657).


  1. Weber DM, Yang JY, Goldman SM, et al. Clin Chem. 2021; in press.

This FAQ is provided for informational purposes only and is not intended as medical advice. A clinician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.

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