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Follicular Lymphoma, EZH2 Mutation, COBAS

Test code(s) 39928


Question 1. What is the Follicular Lymphoma, EZH2 Mutation, COBAS test?

The Follicular Lymphoma, EZH2 Mutation, COBAS test is a real-time, allele-specific PCR test approved by the US Food and Drug Administration (FDA) for the qualitative detection of common mutations in the enhancer of zeste 2 polycomb repressive complex 2 (EZH2) gene in patients with follicular lymphoma.1 Testing is performed on DNA extracted from formalin-fixed, paraffin-embedded (FFPE) follicular lymphoma tumor tissue and identifies the following variants: Y646N, Y646F or Y646X (Y646H, Y646S, or Y646C), A682G, and A692V.


Question 2. What types of specimens are acceptable for this test?

Testing is performed on FFPE follicular lymphoma tumor tissue.


Question 3. How long will it take to receive results? 

Results can be expected 7 days after specimen receipt.


References

    cobas® EZH2 Mutation Test. Package insert. Roche Diagnostics Inc; 2020.

    Bödör C, Grossmann V, Popov N, et al. EZH2 mutations are frequent and represent an early event in follicular lymphoma. Blood. 2013;122(18):3165-3168. doi:10.1182/blood-2013-04-496893

    Morin RD, Johnson NA, Severson TM, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet. 2010;42(2):181-185. doi:10.1038/ng.518 TAZVERIK® (tazemetostat). Highlights of prescribing information. Epizyme Inc; 2020.

    TAZVERIK® (tazemetostat). Highlights of prescribing information. Epizyme Inc; 2020.


This FAQ is provided for informational purposes only and is not intended as medical advice. A clinician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.

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Effective 06/14/2021 to present