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Rivaroxaban

Test code(s) 90981

Peak and trough ranges provided on the patient report are from the published literature, as specified in the table below.

The method is a modified, chromogenic anti-Xa assay in which optical density is directly proportional to the rivaroxaban concentration. The optical density derived from the patient sample is compared to that of calibrators with known rivaroxaban concentration. The resulting concentration is reported in µg/L.

The CV of the rivaroxaban assay is ≤5.8%.

The lower limit of detection for this rivaroxaban assay is 30 µg/L. Rivaroxaban trough levels may be below this value. For this reason, it is suggested that samples be collected at the peak (2-4 hours after the last dose).

Other anti-Xa anticoagulants including unfractionated heparin, low molecular weight heparin (enoxaparin, tinzaparin, dalteparin), and fondaparinux may interfere with the results. This is because the assay does not include a heparin neutralizer.

Gross lipemia, hemolysis >375 mg/dL, and gross icterus also interfere.

This FAQ is provided for informational purposes only and is not intended as medical advice. A clinician’s test selection and interpretation, diagnosis, and patient management decisions should be based on his/her education, clinical expertise, and assessment of the patient.

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