When hereditary breast and ovarian cancer (HBOC) syndrome due to BRCA1 or BRCA2 is suspected and no BRCA1 or BRCA2 mutation testing has been performed, consider ordering the BRCA Panel (BRCA1, BRCA2) test [test code 91863]).
If a familial mutation has been detected by sequencing and/or deletion/duplication studies, the Hereditary Cancer Single Site(s) test (test code 93945) may be considered. Official test results of the family member must be available for laboratory review.
For individuals of Ashkenazi (Eastern European) Jewish heritage, consider performing the BRCA Ashkenazi Jewish Screen [test code 91864] first. Full sequencing may be considered if ancestry also includes non-Ashkenazi Jewish relatives or if other clinical criteria for HBOC syndrome are met. For this scenario, consider BRCA Ashkenazi Jewish Screen with Reflex to BRCA Panel (BRCA1, BRCA2) [test code 92140].
For individuals of Ashkenazi Jewish descent and the familial mutation is not 1 of the 3 Ashkenazi Jewish founder mutations, consider testing for both the founder mutations (BRCA Ashkenazi Jewish Screen [test code 91864]) and the familial mutation (Hereditary Cancer Single Site[s] test [test code 93945]).
Additional tests, such as multigene tests, are available to assess the risk of hereditary gastric cancer. For more information, please visit our website QuestHereditaryCancer.com. To discuss a family history with a Quest Diagnostics genetic counselor, please call Quest Genomics Client Services at 1.866.GENE.INFO (1.866.436.3463).