This test can be useful to identify platelet refractoriness due to the development of the specific antibodies to platelet-specific or HLA class I antigens as a result of pregnancy or transfusion. In addition, this test may be useful in the diagnosis of neonatal alloimmune thrombocytopenia (NAIT) and help differentiate post-transfusion purpura from other causes of thrombocytopenia. Typically, platelet antibody testing is performed after a clinical suspicion of development of a platelet alloantibody.
The results of this assay should not be used as the sole basis for a clinical decision. Reaction patterns should not be used as the sole basis to establish the platelet antibody identity. Results obtained using this assay should be used in conjunction with clinical findings or other serological tests.