Cashew Nut Whole Allergen

Test code 2608

Allergy on the rise with increased consumption in snack foods, Asian foods, baked goods, nut butters, and pestos1,2

  • Sensitized patients have a risk of experiencing severe allergic reactions; the risk has been reported to be even higher than for peanut allergic patients (74% vs. 30%)3
  • Potentially life-threatening, can start early in life and is rarely outgrown2,4

Ana o3

Associated with systemic reactions1

  • Storage protein (2s albumin)1
  • Heat and digestion stable4,5
  • Highly abundant in cashew nuts1

Positive 2608 with negative Ana o3 results may be explained by sensitization to6

  • Other cashew nut storage proteins or lipid transfer protein (LTP)
  • Pollen proteins like profilin or PR-10 proteins
  • Cross-reacting carbohydrate determinants (CCD)

As in all diagnostic testing, a diagnosis must be made by the physician based on test results, individual patient history, the physician’s knowledge of the patient, and the physician’s clinical judgement.

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1. Robotham J, et al. Ana o 3, an important cashew nut (Anacardium occidentale L.) allergen of the 2S albumin family. J Allergy Clin Immunol. 2005; 115(6): 1284-1290.

2. Clark A, et al. Cashew nut causes more severe reactions than peanut: case-matched comparison in 141 children. Allergy. 2007; 62(8): 913-916.

3. Davoren M, et al. Cashew nut allergy is associated with a high risk of anaphylaxis. Arch Dis Child. 2005; 90(10): 1084-1085.

4. Roux K, et al. Tree nut allergens. Int Arch Allergy Immunology. 2003; 131: 234-244.

5. Masthoff L, et al. A systematic review of the effect of thermal processing on the allergenicity of tree nuts. Allergy. 2013; 68: 983-993.