Medicare Coverage and Coding Guide

Policies for JK NGS

States covered under these policies include Connecticut, Maine, Massachusetts, New Hampshire, New York, Rhode Island, and Vermont.

Jurisdiction is determined by the state in which your performing Quest lab is located.

Below is a list of Medicare Coverage Policies for tests or test groups applicable to your state. Diagnosis codes are required for all Medicare orders to document medical necessity.

Click on the links below to find the associated diagnosis codes and frequency information within the policy for the test you want to order. Some links will provide a concise Medicare Coverage and Coding Guide for the coverage policy, while others will direct you to the CMS website policy page.


Medicare National Coverage Determination List
PDF Reference Guides
Medicare Local Coverage
Determination List–JK NGS

PDF Reference Guides


Blood Counts

Blood Glucose Testing

Carcinoembryonic Antigen

Collagen Crosslinks, Any Method

Cytogenetic Studies

Digoxin Therapeutic Drug Assay

Fecal Occult Blood Test

Gamma Glutamyl Transferase

Glycated Hemoglobin/Glycated Protein

Hepatitis Panel/Acute Hepatitis Panel

Histocompatibility Testing

Human Chorionic Gonadotropin

Human Immunodeficiency Virus (HIV) Testing (Prognosis Including Monitoring)

Human Immunodeficiency Virus (HIV) Testing (Diagnosis)

Lipid Testing

Lymphocyte Mitogen Response Assays

Next Generation Sequencing (NGS)

Partial Thromboplastin Time (PTT)

Prostate Specific Antigen

Prothrombin Time (PT)

Serum Iron Studies

Sweat Test

Thyroid Testing

Tumor Antigen by Immunoassay CA 15-3/CA 27.29

Tumor Antigen by Immunoassay CA 19-9

Tumor Antigen by Immunoassay CA 125

Urine Culture, Bacterial


B-type Natriuretic Peptide (BNP) Testing

Genomic Sequence Analysis Panels in the Treatment of Hematolymphoid Diseases

Heavy Metal Testing


Molecular Pathology Hemochromatosis

Molecular Pathology BRCA1 & BRCA2

Molecular Pathology BCR-ABL1 Gene Rearrangment


Urine Drug Testing

Vitamin D Assay Testing

Medicare Local Coverage
Determination List–JK NGS

Links to CMS site policies

Molecular Pathology Procedures (L35000)

Non-covered Services (L33629)






Non-covered ICD-10   
Codes for all lab NCDs
PDF Reference Guides


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