If an individual is not of Ashkenazi Jewish descent, this test should not be ordered. Depending on an individual’s personal and family histories, the BRCA Panel (BRCA1, BRCA2 [test code 91863]) may be appropriate.
If an individual is of Ashkenazi Jewish descent and the familial mutation is unknown, or if the familial mutation is 1 of the 3 Ashkenazi Jewish founder mutations, the BRCA Ashkenazi Jewish Screen (test code 91864) may be appropriate.
If an individual is of Ashkenazi Jewish descent and there is a familial mutation that is not 1 of the 3 Ashkenazi Jewish founder mutations, consider testing for both the founder mutations (BRCA Ashkenazi Jewish Screen [test code 91864]) and the familial mutation (Hereditary Cancer Single Site[s] [test code 93945]).
Additional tests, such as multigene panel tests, are available to help assess the risk of hereditary breast cancer. For more information, please visit our website QuestHereditaryCancer.com. To discuss a family history with a Quest Diagnostics genetic counselor, please call Quest Genomics Client Services at 1.866.GENE.INFO (1.866.436.3463).