Skip to main content

Pain Management Antipsychotics, With Confirmation, Serum and Urine

Test code(s) 94529, 94528

Antipsychotics are medications that can be used to treat mild, moderate, and severe psychosis in patients with schizophrenia and bipolar disorders. These medications can treat thought disorder, hallucinations, and paranoia.

First- and second-generation antipsychotic medications are known as typical and atypical antipsychotics, respectively. Typical and atypical antipsychotics block dopamine D2 receptors in the brain. Atypical antipsychotics also block serotonin 5-hydroxytryptamine receptors.

Examples of typical and atypical antipsychotic drug classes and medications include the following: 

  • Typical (first generation)

o    Chlorpromazine
o    Fluphenazine
o    Haloperidol
o    Loxapine
o    Mesoridazine
o    Thioridazine
o    Thiothixene
o    Trifluoperazine

  • Atypical (second/third generation)

    o   Aripiprazole
    o   Brexpiprazole
    o   Cariprazine
    o   Clozapine
    o   Lurasidone
    o   Molindone
    o   Olanzapine
    o   Quetiapine
    o   Risperidone
    o   Ziprasidone

Antipsychotic drug testing can provide information that improves patient care. Test results can often prompt important clinical discussions with patients. For example, absence of an expected drug could suggest poor adherence or diversion, whereas detection of a nonprescribed licit or illicit drug could raise concerns about substance misuse. Discrepancies between expected and actual results could also call attention to patient intolerance to medication side effects, drug-drug interactions, or potential medical factors affecting drug disposition. 1,2

Test codes 94529 and 94528 are performed at Quest Diagnostics Nichols Institute, Valencia, CA. 

Test Codes 94529 and 94528:

Test codes 94529 and 94528 use liquid chromatography/tandem mass spectrometry (LC/MS/MS) for both the presumptive analysis and the definitive quantitative confirmation.

Multiple antipsychotic drugs from both classes (typical and atypical) are included in the tests. A list of the drugs and their associated cutoffs can be found at the end of this document.

Table listing antipsychotic drug monitoring tests (click to open in new tab).

Negative results indicate the absence of drug and/or metabolite or concentrations below the assay cutoff. Positive results indicate the presence of the respective drug and/or metabolite.

Some drugs are available to be ordered individually. Please go to our test directory to locate additional tests or contact your sales representative.

If you have any questions regarding this information or require assistance with interpreting these drug test results, please contact a Quest Diagnostics toxicology specialist at 1.877.40.RXTOX (1.877.407.9869). Specialists are available to assist you Monday through Friday from 8 AM to 10 PM Eastern time.

This FAQ is provided for informational purposes only and is not intended as medical advice. Test selection and interpretation, diagnosis, and patient management decisions should be based on the clinician’s education, clinical expertise, and assessment of the patient.

Document FAQS.191 Version: 1
Version 1 effective 02/15/2022 to present

Version 0 effective 04/13/2018 to 02/15/2022