The Comprehensive Hereditary Cancer Panel includes 66 genes associated with a broad spectrum of hereditary cancers. This can include, but is not limited to, cancers of the breast, colon, endometrium, ovary, pancreas, prostate, rectum, neuroendocrine system, and other tissues. This panel would be used if the clinician desires comprehensive analysis of genes related to a variety of cancers containing clinically actionable genes as well as emerging genes.
The overview below offers a quick glance at our comprehensive offerings for you and your patients.
Comprehensive Hereditary Cancer Panel
Test name |
Test code |
GSP or CPT coding |
FAQ |
| Comprehensive Hereditary Cancer Panel (66 genes) Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2 |
For breast: 81432, 81433 For colon: 81435, 81436 |
Guideline-Based Hereditary Cancer Panel
The Guideline-Based Hereditary Cancer Panel includes clinically actionable analysis of 32 genes including moderate to high risk to provide clinically actionable results that give you a clearer picture of your patient’s potential risk for hereditary cancers, including breast, colon, prostate, uterine, melanoma, and other hereditary cancers. This panel would be used if the clinician desires comprehensive analysis of genes related to more common cancers.
Test name |
Test code |
GSP or CPT coding |
Comprehensive Hereditary Cancer Panel (66 genes) Multi-cancer, 66-gene panel tests for variants in these genes: APC, ATM, AXIN2, BAP1, BARD1, BLM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN1B, CDKN2A, CHEK2, DICER1, EGFR, EPCAM, GREM1, FANCA, FANCC, FANCM, FH, FLCN, GALNT12, HOXB13, MAX, MEN1, MET, MITF, MLH1, MRE11 (MRE11A), MSH2, MSH3, MSH6, MUTYH, NBN, NF1, NTHL1, PALB2, PMS2, POLD1, POLE, POT1, PTCH1, PTEN, RAD50, RAD51C, RAD51D, RECQL, RET, SDHA, SDHAF2, SDHB, SDHC, SDHD, SMAD4, SMARCA4, STK11, SUFU, TMEM127, TP53, TSC1, TSC2, VHL, XRCC2 |
For breast: 81432, 81433 For colon: 81435, 81436 |
Sub-panels for hereditary cancers
The panels include genes selected by following medically accepted guidelines and can be collected using saliva, blood, or fibroblast.
Test name |
Test code |
GSP or CPT coding |
FAQ |
Hereditary Breast Cancer Panel (18 genes) |
81432, 81433 |
|
|
Hereditary Colorectal Cancer Panel (20 genes) |
81435, 81436 |
|
|
Hereditary Endocrine Cancer Panel (12 genes) |
81437, 81438 |
||
BRCA Panel Plus (7 genes) |
81162, 81307, 81321, 81323, 81351, 81404, 81405, 81406, 81479 |
Additional hereditary cancer risk tests
Certain things make it more likely that cancers in a family are caused by a hereditary cancer syndrome, such as:
- Many cases of the same type of cancer (especially if it is an uncommon or rare type of cancer)
- Cancers occurring at younger ages than usual (typically cancer in someone younger than 50 years old)
- More than 1 type of cancer in a single person (such as a person with both breast and ovarian cancer)
- Cancers occurring in both of a pair of organs (such as both eyes, both kidneys, or both breasts)
- Cancer occurring in the sex not usually affected (such as breast cancer in a male)
- Cancer occurring in multiple generations (such as in a parent, child, and grandchild)
Test name |
Test code |
GSP or CPT coding |
FAQ |
Lynch syndrome |
|||
Lynch Syndrome Panel (5 genes) |
81295, 81297, 81292, 81294, 81298, 81300, 81317, 81319, 81403 |
||
Other cancer risks |
|||
Nevoid Basal Cell Carcinoma (NBCCS) (Gorlin) Syndrome Panel (PTCH1, SUFU) |
81479 |
||
Tuberous Sclerosis Complex Panel (TSC1, TSC2) |
81405, 81406 (x2), 81407 |
||
Juvenile Polyposis Panel (BMPR1A, SMAD4) |
81405, 81406, 81479 |
||
Single-site test
Single-site testing is available when there is a known variant in the family. This test is available for any of the 66 genes on our Comprehensive Hereditary Cancer Panel.
Test name |
Test code |
GSP or CPT coding |
FAQ |
Hereditary Cancer Single Site(s) |
Please call Genomic View Client Services 1.866.GENE.INFO (1.866.436.3463) for more information |
Single-gene test
We have added single-gene tests for specific instances when a patient’s personal and/or family history points to a specific gene instead of a broader evaluation.
Test name |
Test code |
GSP or CPT coding |
FAQ |
APC Sequencing and Deletion/Duplication |
81201, 81203 |
||
ATM Sequencing and Deletion/Duplication |
81408, 81479 |
||
BAP1 Sequencing and Deletion/Duplication |
81479 |
||
BLM Sequencing and Deletion/Duplication |
81479 |
||
CDH1 Sequencing and Deletion/Duplication |
81406, 81479 |
||
CDKN2A Sequencing and Deletion/Duplication |
81404, 81479 |
||
CHEK2 Sequencing and Deletion/Duplication |
81479 |
||
Lynch Syndrome, MSH2 Sequencing and Deletion/Duplication (Including EPCAM) |
81295, 81297, 81403 |
||
FH Gene Sequencing and Deletion/Duplication |
81405, 81479 |
||
FLCN Sequencing and Deletion/Duplication |
81479 |
||
HOXB13 Sequencing and Deletion/Duplication |
81479 |
||
MEN1 Sequencing and Deletion/Duplication |
81405, 81404 |
||
MITF Gene Analysis |
81479 |
||
Lynch Syndrome, MLH1 Sequencing and Deletion/Duplication |
81292, 81294 |
||
Lynch Syndrome, MSH6 Sequencing and Deletion/Duplication |
81298, 81300 |
||
MUTYH Sequencing and Deletion/Duplication |
81406, 81479 |
||
NF1 Sequencing and Deletion/Duplication |
81408, 81479 |
||
PALB2 Sequencing and Deletion/Duplication |
81307, 81479 |
||
Lynch Syndrome, PMS2 Sequencing and Deletion/Duplication |
81317, 81319 |
||
PTEN Sequencing and Deletion/Duplication |
81321, 81323 |
||
RET Sequencing and Deletion/Duplication |
81406, 81479 |
||
SMARCA4 Sequencing and Deletion/Duplication |
81479 |
||
STK11 Sequencing and Deletion/Duplication |
81405, 81404 |
||
Li-Fraumeni Syndrome, TP53 Sequencing and Deletion/Duplication |
81351, 81479 |
||
VHL Sequencing and Deletion/Duplication |
81404, 81403 |
Test codes may vary by location. Please contact your local laboratory for more information.
Components of panels may be ordered separately.
The CPT® codes provided are based on American Medical Association guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
Only a patient’s treating physician can make diagnoses, prognostic or treatment decisions based on the knowledge of the patient, history and clinical/educational experience. Quest lab testing provides information for the physician to use in helping make such decisions.
Questions? Connect with a team member.
Please talk to your Quest representative for ordering information on our comprehensive portfolio of hereditary cancer test offerings.
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