PD-L1 tests offered at Quest Diagnostics

Programmed death ligand (PD-L1) is also called an Immune check point inhibitor.

It is present in multiple tumor types. PD-L1 is expressed on activated T-cells and binding of PD-1 by its ligand PD-1 inhibits T-cell mediated cytotoxicity. Some cancer cells express PD-L1 on their surface thus suppressing T-cell mediated attack on cancer cells. Immunotherapy employing monoclonal antibodies that block PD-1 or PD-L1 have shown significant antitumor effects in many cancers including non-small cell lung carcinoma.

Tumoral PD-L1 expression is seen in multiple tumor types including NSCLC, Melanoma, Urothelial carcinoma.

The different PD-L1 tests offered at Quest appear below.

Test Name & Comp Test Code CPT Code Specimen Type
PD-L1 Lung (Pembrolizumab), IHC 93279 88360 FFPE: Lung
PD-L1 Lung (Nivolumab), IHC 93359 88360 FFPE: Lung
PD-L1 Melanoma (Nivolumab), IHC 93793 88360 FFPE: Melanoma
PD-L1 Bladder (Atezolizumab), IHC 94047 88360 FFPE: Bladder
PD-L1, IHC with Interpretation 94007 88360 FFPE: Cytology Cell block of any tumor/site type acceptable


Download the PD-L1 Overview here

Download the PD-L1 Test List here

Contact your Quest Diagnostics sales representative, call 1.866.MY.QUEST (1.866.697.8378) or visit QuestDiagnostics.com.

The CPT codes provided are based on American Medical Association guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.