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Test Name

Cardio IQ® Insulin Resistance Panel with Score

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

CPT Code(s)**

83525, 84681
**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.

Includes

Insulin, Intact, LC/MS/MS
C-Peptide, LC/MS/MS
Insulin Resistance Score

Methodology

Immunocapture Liquid Chromatography/Tandem Mass Spectrometry

Reference Range(s)

Insulin, Intact, LC/MS/MS ≤16 uIU/mL
C-Peptide, LC/MS/MS 0.68-2.16 ng/mL
Insulin Resistance Score ≤66

Clinical Significance

The determination of insulin in serum is primarily used for the diagnosis of glycemic disorders in diabetic and pre-diabetic patients in the assessment of insulin resistant syndromes. Insulin is synthesized by the pancreatic beta cell as a precursor, proinsulin. Proinsulin is processed to insulin and C-peptide, a contiguous peptide between the insulin A and B chains, as it passes through the cell. The C-peptide in the proinsulin ensures correct folding and processing of proinsulin as it passes through the cell. Both insulin and C-peptide are released together from the beta cells in response to increased glucose levels. Because of differences in half-life and hepatic clearance, peripheral blood levels of C-peptide and insulin are no longer equimolar but remain highly correlated. A steady-state plasma glucose test in individuals undergoing an insulin suppression test to assess insulin resistance found that the combination of insulin and C-peptide was a better indicator of insulin resistance than either one individually.

Test FAQ

CardioIQ® Insulin Resistance Panel with Score

Alternative Name(s)

IRS,IR Risk Score,CIQ IRS,IRR Score,CardioIQ®,IR Score,CIQ Insulin

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Cardio IQ® Insulin Resistance Panel with Score
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