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Osteocalcin, N-MID

Test Code


CPT Code(s)


Patient Preparation

Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation.

Preferred Specimen(s)

1 mL serum

Minimum Volume

0.5 mL

Collection Instructions

Allow blood to clot at room temperature (20-26° C) and centrifuge immediately to separate the serum from the cells. Freeze as soon as possible.

Specimen Container

Plastic screw-cap vial

Transport Temperature


Specimen Stability

Room temperature: Unacceptable
Refrigerated: 24 hours
Frozen 21 days

Reject Criteria

Hemolysis • Heat inactivated specimens • Specimens stabilized with azide • Patient administered with biotin within 8 hours


Electrochemiluminescence (ECLIA)

Performing Laboratory

Quest Diagnostics Nichols Institute
14225 Newbrook Drive
Chantilly, VA 20153

Setup Schedule

Set up: Mon-Fri a.m.; Report available: Next day

Reference Range(s)

  Male (ng/mL) Female (ng/mL)
0-4 Years Not established Not established
5-9 Years 47-142 47-142
10-13 Years 49-167 49-167
14-17 Years 26-203 14-85
>17 Years 9-38 8-32

Clinical Significance

Osteocalcin, the most abundant non-collagen protein in bone matrix, is a bone-specific, calcium binding protein. Serum osteocalcin levels are related to the rate of bone turnover in various disorders of bone metabolism, e.g., osteoporosis, primary and secondary hyperparathyroidism, and Paget's disease.

LOINC®' Code(s)

The Result and LOINC information listed below should not be used for electronic interface maintenance with Quest Diagnostics. Please contact the Quest Diagnostics Connectivity Help Desk for more information at 800-697-9302.

NOTE: The codes listed in the table below are not orderable Test Codes.

Result NameLOINC CodeComponent Name
16322Osteocalcin, N-MID2697-1Osteocalcin

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

LOINC assignment is based on a combination of test attributes, including the method used by the performing laboratory. For tests not performed by Quest Diagnostics, codes are assigned by the performing laboratory.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.