Co-testing makes
a difference

A more complete picture of a woman’s cervical health

Co-testing involves a Pap and HPV test being ordered on the same sample—regardless of the Pap result. Reflex testing is a sequential approach and only tests for HPV based on the Pap result—which means that it may not provide a complete picture of a woman’s cervical health.

Co-testing versus reflex testing: 2 different approaches

Reflex testing
(sequential approach)1

HPV test is only performed in the event of an ASC-US Pap1

(both tests run together)1

HPV test is performed regardless of Pap result1
A Pap test and an HPV test are ordered together to increase the probability of detecting CIN3

How co-testing helps

With a national Pap ASC-US rate of about 4.3%, reflex testing in women 30 to 65 means

of those patients would not get an HPV test2

This can potentially result in:

  • Failure to diagnose persistent high-risk infections1
  • Subsequent risk for progression to HSIL, CIN3, or cancer1
  1. Committee on Practice Bulletins—Gynecology. ACOG practice bulletin number 131: screening for cervical cancer. Obstet Gynecol. 2012;120(5):1222-1238. doi: http://10.1097/AOG.0b013e318277c92a
  2. Eversole GM, Moriarty AT, Schwartz MR, et al. Practices of participants in the college of American pathologists interlaboratory comparison program in cervicovaginal cytology, 2006. Arch Pathol Lab Med. 2010;134(3):331-335. doi: 10.1043/1543-2165-134.3.331