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CA 19-9, Serum

CA 19-9, Serum

Test Highlight

CA 19-9, Serum

  

Clinical Use

  • Monitor therapy in individuals with pancreatic cancer

  • Monitor therapy in selected individuals with gastric and colon cancer

Clinical Background

CA 19-9 is a mucin-glycoprotein derived from a human colorectal carcinoma cell line. It is related to the Lewis blood group protein and is present in epithelial tissue of the stomach, gall bladder, pancreas, and prostate. Blood levels may be increased modestly in patients with pancreatitis, biliary tract disease, inflammatory bowel disease, and cystic fibrosis. The distribution of CA 19-9 in healthy individuals, benign disorders, and malignant disease is reflected in Tables 1 and 2.

Method

Immunochemiluminometric assay

Interpretive Information

CA 19-9 concentrations are increased in patients with pancreatic, gastric, and colon cancer as well as in some non-malignant conditions (Tables 1 and 2). Increasing levels generally indicate disease progression, whereas decreasing levels suggest therapeutic response.

Table 1. Distribution of CA 19-9

Patient Group

Number of Patients

% with CA 19-9

>37.0 U/mL

Healthy Subjects 1020 0.6

Benign Disease

 

 

Pancreatic

21 0

Inflammatory Bowel Disease

56 2

Polyps

27 0

Other Diseases

219 2

 Malignant Disease

 

 

Pancreatic Adenocarcinoma

80 79

Gastric Adenocarcinoma

24 50

Colorectal Adenocarcinoma

Advanced

164 46

Localized

25 8

Inactive

21 0

Reference: DelVillano BC, et al. Clin Chem. 1983;29:549-552.

Table 2. Distribution of CA 19-9

Patient Group   Number of Patients

% with CA 19-9

>37 U/mL              >75 U/mL
Nonmalignant Disease

Abdominal Pain

34 3 3

Jaundice

58 19 12

Malabsorption 

7 0 0

Pancreatic 

48 19 6

Renal Failure

10 20 0

Malignant Disease

 

 

 

Pancreas

37 89 86

Reference: Steinberg WM, et al. Gastroenterology. 1986;90:343-349.

 

Content reviewed 12/2012

 
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