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Test Name

Chlamydia Antibody (IgG)

CPT Code(s)



Enzyme Immunoassay (EIA)

Reference Range(s)

EIA value Explanation of Test Result
 ≤0.90 Negative - No Chlamydia IgG Antibody detected
0.91-1.09 Equivocal
≥1.10 Positive - Chlamydia IgG Antibody detected
The presence of Chlamydia IgG Antibody suggests a current or past infection with one or more of three Chlamydia species: C. trachomatis, C.pneumoniae or C. psittaci. Sera collected early in the course of the infection may not have detectable levels of IgG antibody.
If a current or recent infection is suspected, performing a Chlamydia IgM test on a single serum may yield clinically useful information.

Clinical Significance

Chlamydia trachomatis is associated with infections of the mucous membranes of the urogenital system, the upper respiratory tract, and the eye. In industrialized countries, C. trachomatis usually causes sexually transmitted disease. In developing countries, it is the major cause of preventable blindness (trachomatis). Sexually transmitted diseases caused by C. trachomatis include nongonococcal urethritis, cervicitis, salpingitis, epididymitis, proctitis and Lymphogranuloma venereum. Infections are often asymptomatic. Thus, infected individuals may unknowingly transmit chlamydial disease to others. Coinfection with C. trachomatis and Neisseria gonorrhoeae is common, with multiple chlamydial infections of the upper respiratory tract occurring primarily in newborns exposed at parturition through an infected birth canal. Approximately 10-20% of such infants develop pneumonia and 50% develop inclusion conjunctivitis. In adults, eye disease is often transmitted by the hands from genital secretions or from eye secretion of infected babies. Isolation in tissue culture remains the reference method for diagnosis of chlamydial infection, especially when testing individuals under the age of 13 years. The usefulness of serological tests depends on the site of infection, duration of disease, infecting serovars and pre-vious exposure to chlamydial antigens. Because C. trachomatis is ubiquitous, there is a high prevalence of antibodies in sexually active populations. Antibodies may persist even after treatment, making assessment of a single IgG titer difficult. Consequently, serological diag-nosis is seldom used to diagnose active, superficial genital tract infections.

Bowie, W. R. And K. K. Holmes. 1990. Chlamydial trachomatis (trachoma, perinatal infection, Lymphogranuloma venereum, and other genital infections). PP. 1426-1440. In: G. L. Mandell, et al. , (EDS) Principles and Practice of Infectious Diseases, 5th ed. , Churchill Livingstone, Inc. , NY.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

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Chlamydia Antibody (IgG)