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Test Name

Beta-Amyloid 42/40 Ratio and Apolipoprotein E (APOE) Isoform Panel, CSF

CPT Code(s)

82542 (x2), 82172

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Reference Range(s)

See Laboratory Report

Clinical Significance

This test for CSF Beta-Amyloid and CSF/Serum Apolipoprotein E by LC-MS/MS monitors both CSF beta-amyloid 40 (AB40) and 42 (AB42) endogenous peptides, rather than only AB42. Total ApoE and ApoE isoform analysis, in conjunction with the AB42/40 ratio, can aid in assesing disease. The quantitation of both AB peptides permits the normalization of beta amyloid levels circulating in cerbrospinal fluid in different patients by using a ratio of beta-amyloid 42/beta amyloid 40, resulting in an improved sensitivity for monitoring cognitive impairment that can progress to Alzheimer's disease.

Alternative Name(s)

ApoE3,Alzheimer's Disease (AD),ABeta 42,AB40,ApoE4,ABeta 40,AB42,ApoE2

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Beta-Amyloid 42/40 Ratio and Apolipoprotein E (APOE) Isoform Panel, CSF
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