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Test Name

Autoimmune Neurology Antibody Comprehensive Panel with Reflexes, Serum

CPT Code(s)

86255 (x20), 86341 (x2), 84182 (x11), 83519 (x5)

Includes

If Autoimmune Neurology Antibody Comprehensive Panel suggests NMO-5 IgG, then Aquaporin-4 Antibody will be performed at an additional charge (CPT code(s): 86255).
If Aquaporin-4 Ab is positive, then titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests ANNA-3, the titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests PCA2, then titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests PCA-Tr and Paraneoplastic Ab, WB shows DNER negative and Yo Negative, then DNER, Ab, IFA will be performed at an additional charge (CPT code(s): 86255).
If DNER, Ab, IFA is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If Autoimmune Neurology Antibody Comprehensive Panel suggests Myelin Antibody, then Myelin Ab titer will be performed at an additional charge (CPT code(s): 86256), and Myelin Assoc. Glycoprotein (MAG) Antibody w/Reflex to MAG-SGPG & MAG, EIA will be performed at an additional charge (CPT code(s): 84182, 83520 x2).
If MAG Antibody (IgM), Western Blot is positive, then both MAG-SGPG Antibody (IgM), EIA and MAG Antibody (IgM), EIA will be performed at additional charge (CPT code(s): 83520 x2).
If NMDAR1 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If AMPAR1 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If AMPAR2 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If LGI-1 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If CASPR2 Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If DPPX Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If GABA-B Receptor Ab is positive, then a titer will be performed at an additional charge (CPT code(s): 86256).
If AChR Binding is Negative, then AChR Modulating Ab will be performed at an additional charge (CPT code(s): 83519).
If AChR Binding is Positive (≥0.50), then AChR Blocking Ab will be performed at an additional charge (CPT code(s): 83519).
If AChR Binding is Equivocal (0.31-0.49), then both AChR Blocking and AChR Modulating will be performed at additional charge (CPT code(s): 83519).
If Anti-Striated Muscle Ab Screen is Positive, then Anti-Striated Muscle Ab Titer will be performed at an additional charge (CPT code(s): 86256).

Methodology

See individual tests

Reference Range(s)

See Laboratory Report

Clinical Significance

A comprehensive approach to detection of known antineuronal autoantibodies aids the diagnosis of paraneoplastic syndromes and autoimmune encephalopathies and related conditions. Identification of specific antineuronal autoantibodies may direct evaluation for idiopathic autoimmune disease or underlying often occult malignancy. Characterization of autoantibody specificity may allow syndromic classification and assist in diagnosis and management. Antineuronal antibodies are detected and characterized based on indirect immunofluorescence staining pattern on multiple neuronal, non-neuronal tissues, and transformed substrate cells, and radioimmunoassays, and line blot analysis.

Alternative Name(s)

Paraneoplastic Abs, Serum, Comprehensive

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Autoimmune Neurology Antibody Comprehensive Panel with Reflexes, Serum
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