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Test Name

Watson Genomics from Quest Diagnostics, Core

CPT Code(s)

81445

Physician Attestation of Informed Consent

This germline genetic test requires physician attestation that patient consent has been received if ordering medical facility is located in AK, DE, FL, GA, IA, MA, MN, NV, NJ, NY, OR, SD or VT or test is performed in MA.

Clinical Significance

This multiplex panel will allow physicians to choose the most appropriate therapy for their patients based on the alterations found in the individual's tumor sample DNA. Guidelines exist for using results from many of these genes for selection of FDA approved therapies. By testing for other genes the physician can become aware of alternative treatments available to the patient based on presence of mutations in other genes the physicians might not have considered. Additional genes indicate prognosis of those patients with mutations, thus allowing physicians and patients to choose more or less aggressive therapies. Finally, mutations found in additional genes will qualify patients for ongoing or planned clinical trials

Includes

AKT1, AKT2, ALK, AR, AURKA, BAP1, BRAF, BRCA1, BRCA2, CDKN2A, CDKN2B, CTNNB1, DDR2, EGFR, EP300, ERBB2, ERBB3, ERBB4, ESR1, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, HRAS, IDH1, JAK2, KDR, KIT, KRAS, MAP2K1, MET, MTOR, MYC, MYCN, NRAS, NTRK1, PDGFRA, PDGFRB, PIK3CA, PTCH1, PTEN, RET, ROS1, TERT, TMPRSS2, TP53, TSC1, VHL
MSI of 5 loci may be performed dependent upon specimen(s) submitted.

Methodology

Next Generation Sequencing/Illumina NextSeq

Reference Range(s)

See Laboratory Report

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Watson Genomics from Quest Diagnostics, Core
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