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Test Name

ANA Screen,IFA,with Reflex to Titer and Pattern/Rheumatoid Arthritis Panel2 (New)

CPT Code(s)

86038, 86200, 86431, 83520

Includes

ANA Screen, IFA, with Reflex to Titer and Pattern; Rheumatoid Factor; Cyclic Citrullinated Peptide (CCP) Antibody IgG; 14-3-3 eta Protein*

If ANA Screen, IFA is positive, then ANA Titer and Pattern will be performed at an additional charge (CPT code(s): 86039).

Methodology

See individual tests

Reference Range(s)

See individual tests

Clinical Significance

Anti-nuclear antibody (ANA) tests are a general indicator of autoimmune disease. Many people with RA have positive ANA tests. Antinuclear antibodies are associated with rheumatic diseases including Systemic Lupus Erythematosus (SLE), mixed connective tissue disease, Sjogren's syndrome, scleroderma, polymyositis, CREST syndrome, and neuropsychiatric SLE.
Early diagnosis of rheumatoid arthritis (RA), i.e., diagnosis before significant joint erosion occurs, is difficult. Psoriatic arthritis can also be difficult to diagnose clinically early in the disease process, and there are no specific biomarkers. The 14-3-3eta protein is an emerging biomarker for RA and erosive psoriatic arthritis diagnosis. It may play a biologic role in the joint erosive process. Blood levels may be elevated in patients with RA, but not in other diseases including psoriasis, osteoporosis, gout, ulcerative colitis, type 1 diabetes, systemic lupus erythematosus, Crohn disease, primary Sjogren syndrome, scleroderma, and multiple sclerosis. The 14-3-3eta protein, used in conjunction with rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody, may improve diagnostic sensitivity in the early diagnosis of RA. It may also help differentiate those psoriasis patients with psoriatic erosive arthritis joint damage from those without joint damage.

Alternative Name(s)

FANA,IdentRA®,Fluorescent ANA,Progressive ANA,RA Panel 2,Hep-2,Antinuclear Antibody Screen

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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ANA Screen,IFA,with Reflex to Titer and Pattern/Rheumatoid Arthritis Panel2
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