Test Center

My Recent Searches

  • No Recent Search.

My Tests Viewed

  • No Test Viewed.
Test Name

KIT D816 Mutation Analysis (Mastocytosis)

CPT Code(s)

81402

Methodology

DNA Sequencing

Reference Range(s)

Not detected

Clinical Significance

Point mutation of the KIT oncogene at codon 816 (D816V) is seen in >90% of systemic mastocytosis (SM) cases. The presence of KIT D816V mutation is one of the minor criteria for diagnosis of SM and mutation testing can assist in diagnosis, particularly in limited specimens. KIT D816 mutations, including D816V, D816H and D816Y, are also the most common KIT mutations seen in the core-binding factor acute myeloid leukemia (AML). In both t(8;21) and inv(16)/t(16;16) AML, cases with KIT D816 mutation are associated with worse outcomes than unmutated cases.
This PCR-based DNA pyrosequencing assay sensitively detects the KIT D816V mutation down to 2%. If KIT mutation testing of gastrointestinal stromal tumor (GIST) or melanoma is needed, test code 19961 should be used instead, which tests for exons 8, 9, 11, 13 and 17 of the KIT gene by Sanger sequencing.

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

91772X
91772
91772
91772
91772
91772X
91772
91772
91772X
151760
91772
91772
91772
91772
91772
91772
91772
91772
91772
91772
91772
91772
91772X
91772
91772
91772X
151760
91772
91772
91772
KIT D816 Mutation Analysis (Mastocytosis)
91772