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Test Name

Rheumatoid Arthritis Diagnostic IdentRA® Panel 2

CPT Code(s)

86431, 86200, 83520

Includes

Rheumatoid Factor, Cyclic Citrullinated Peptide (CCP) Antibody (IgG), 14-3-3 eta Protein*

Methodology

Enzyme Linked Immunosorbent Immunoassay (ELISA) • Immunoturbidimetric Assay

Reference Range(s)

Rheumatoid Factor <14 IU/mL
CCP Antibody (IgG)  
  Negative <20 units
  Weak positive 20-39 units
  Moderate positive 40-59 units
  Strong positive >59 units
14-3-3 eta Protein <0.2 ng/mL

Clinical Significance

Early diagnosis of rheumatoid arthritis (RA), ie, diagnosis before significant joint erosion occurs, is difficult. Psoriatic arthritis can also be difficult to diagnose clinically early in the disease process, and there are no specific biomarkers. The 14-3-3η (eta) protein is an emerging biomarker for RA and erosive psoriatic arthritis diagnosis. It may play a biologic role in the joint erosive process. Blood levels appear to be elevated in patients with RA, but not in other diseases including psoriasis, osteoporosis, gout, ulcerative colitis, type 1 diabetes, systemic lupus erythematosus, Crohn disease, primary Sjögren syndrome, scleroderma, and multiple sclerosis. The 14-3-3η protein, used in conjunction with rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody, may improve diagnostic sensitivity in the early diagnosis of RA. It may also help differentiate those with psoriatic arthritis joint damage from those without joint damage.

Alternative Name(s)

IdentRA® Rheumatoid Factor

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Rheumatoid Arthritis Diagnostic IdentRA® Panel 2
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