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Rheumatoid Arthritis Diagnostic IdentRA® Panel 2
86431, 86200, 83520
Rheumatoid Factor, Cyclic Citrullinated Peptide (CCP) Antibody (IgG), 14-3-3 eta Protein*
Enzyme Linked Immunosorbent Immunoassay (ELISA) • Immunoturbidimetric Assay
|Rheumatoid Factor||<14 IU/mL|
|CCP Antibody (IgG)|
|Weak positive||20-39 units|
|Moderate positive||40-59 units|
|Strong positive||>59 units|
|14-3-3 eta Protein||<0.2 ng/mL|
Early diagnosis of rheumatoid arthritis (RA), ie, diagnosis before significant joint erosion occurs, is difficult. Psoriatic arthritis can also be difficult to diagnose clinically early in the disease process, and there are no specific biomarkers. The 14-3-3η (eta) protein is an emerging biomarker for RA and erosive psoriatic arthritis diagnosis. It may play a biologic role in the joint erosive process. Blood levels appear to be elevated in patients with RA, but not in other diseases including psoriasis, osteoporosis, gout, ulcerative colitis, type 1 diabetes, systemic lupus erythematosus, Crohn disease, primary Sjögren syndrome, scleroderma, and multiple sclerosis. The 14-3-3η protein, used in conjunction with rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibody, may improve diagnostic sensitivity in the early diagnosis of RA. It may also help differentiate those with psoriatic arthritis joint damage from those without joint damage.
IdentRA® Rheumatoid Factor
To view specimen requirements and codes please Select a regional laboratory.
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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.