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Test Name

Herpes Simplex Virus (HSV) Antibody Panel, ELISA/IFA, CSF

To view specimen requirements and codes please Select a regional laboratory.

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CPT Code(s)**

86695 (x2), 86696 (x2)
**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.

Includes

Herpes Simplex Virus 1/2 (IgG) Type-Specific Antibodies; Herpes Simplex Virus 1/2 Antibody (IgM), IFA with Reflex to Titer

If HSV 1 IgM screen is positive, HSV 1 IgM Titer will be performed at an additional charge (CPT code(s): 86695).
If HSV 2 IgM Screen is positive, HSV 2 IgM Titer will be performed at an additional charge (CPT code(s): 86696).

Methodology

Enzyme Linked Immunosorbent Assay (ELISA) • Immunofluorescence Assay (IFA)

Reference Range(s)

HSV 1/2 (IgG) Type-Specific Antibodies, CSF

HSV 1 IgG Index  Negative 
HSV 2 IgG Index  Negative 

HSV 1/2 Antibody (IgM), IFA, CSF
HSV 1 IgM Screen Negative
HSV 2 IgM Screen Negative

Clinical Significance

Detection of HSV type-specific IgG in CSF may indicate central nervous system infection by that HSV type.
The IFA procedure for measuring IgM antibodies to HSV 1 and HSV 2 will detect both type-common and type-specific HSV antibodies. Thus, detection of antibodies to both HSV 1 and HSV 2 may represent cross-reactive HSV antibodies rather than exposure to both HSV 1 and HSV 2.

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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HERPES G/M CSF
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Herpes Simplex Virus (HSV) Antibody Panel, ELISA/IFA, CSF
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