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Test Name

T3 Reverse, LC/MS/MS

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CPT Code(s)**

84482
**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Reference Range(s)

8-25 ng/dL

Clinical Significance

3,3',5'-Triiodothyronine (reverse T3, rT3) is, along with 3,3,5'-Triiodothyronine (T3) a deiodinated metabolite of thyroxine (T4), the major secretory product of the thyroid gland and is secreted into the bloodstream. Unlike T3, however, rT3 is thought to be metabolically inert.
The process of 5'-monodeiodination that converts T4 to T3, and rT3 to diiodothyronine (DTT) is inhibited in a wide variety of conditions, collectively referred to as nonthyroidal illnesses (NTI) or the 'euthyroid sick' state. These conditions include fasting, malnutrition, poorly controlled diabetes mellitus, trauma, surgery, and systemic illness. Consequently, in patients with NTI the serum T3 level typically decreases, and the rT3 often, but not always, increases.

Alternative Name(s)

RT3,rT3 ,Triiodothyronine Reverse,Reverse Triiodothyronine,Reverse T3

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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T3 Reverse, LC/MS/MS
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