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Test Name

Thyroid, FNA Cytomorphology with Molecular Reflex

CPT Code(s)

88173

Includes

Comprehensive Assessment will be added to all Molecular Reflex tests.

If indicated, test may reflex to one or more of following tests at an additional charge:
BRAF Mutation Analysis, Papillary Thyroid Cancer (CPT Code(s): 81210); RET/PTC Rearrangement, Thyroid Cancer (CPT Code(s): 81311); PAX8/PPAR [gamma] Translocation, Thyroid Cancer Translocation (CPT Code(s): 81401); RAS Mutation Analysis, Thyroid Cancer (CPT Code(s): 81403, 81311,81275, 81276)
Level IV, Surgical Pathology (CPT Code(s): 88305); Histopathology Special Stains-Miscellaneous (CPT Code(s): 88313); Immunostain(s) with Interpretation (CPT Code(s): 88342 for first and 88341 for each additional).
Most common are: Calcitonin, IHC; CD20, IHC; CD3, IHC; PTH, IHC; TTF 1, IHC; Thyroglobulin, IHC

Methodology

Cytomorphology Review • Reflex: PCR-based Molecular Testing

Reference Range(s)

See Laboratory Report

Clinical Significance

This assay provides morphologic review along with appropriate molecular testing for diagnosis of thyroid samples obtained by fine needle aspirate (FNA). Any molecular testing required will be reflexed based on cytologic findings and a comprehensive assessment issued summarizing the overall findings.
Papillary thyroid cancer (PTC) is associated with BRAF V600E mutation (40-50% of cases) and RET overexpression through juxtaposition to the PTC genes by chromosome fusion (5-40% of cases). Follicular thyroid carcinomas are specifically associated with PPARG-PAX8 gene fusions in 25-50% of cases. NRAS, HRAS and KRAS mutations are more commonly associated with follicular thyroid neoplasms than PTC.

For reflex algorithm for molecular testing, see:
http://questdiagnostics.com/testcenter/testguide.action?fn=EndoMetab/Thyroid/TG_Thyroid_Cancer.htm

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Thyroid, FNA Cytomorphology with Molecular Reflex
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