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RAS Mutation Analysis, Thyroid Cancer
81403, 81311, 81275, 81276
|HRAS Mutation||Not detected|
|KRAS Mutation||Not detected|
|NRAS Mutation||Not detected|
Activating mutations in the RAS genes, particularly NRAS, have been detected in follicular thyroid carcinomas (up to 40%) and papillary thyroid carcinomas (up to 10%), but are also seen commonly in follicular adenomas. Correlation with morphologic and clinical findings is thus required. Follicular thyroid neoplasms with RAS mutations may behave more aggressively than those without. The assay tests for mutations in codon 12 and 13 (exon 1) and codon 61 (exon 2) in HRAS, KRAS and NRAS by a DNA-based sequencing method, with an approximate sensitivity of 1 to 5% mutation-bearing cells in a mixed sample. This assay will not detect RAS mutations outside the codons listed above.
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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
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