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Test Name

RAS Mutation Analysis, Thyroid Cancer

CPT Code(s)

81403, 81311, 81275, 81276

Methodology

Pyrosequencing

Reference Range(s)

HRAS Mutation Not detected
KRAS Mutation Not detected
NRAS Mutation Not detected

Clinical Significance

Activating mutations in the RAS genes, particularly NRAS, have been detected in follicular thyroid carcinomas (up to 40%) and papillary thyroid carcinomas (up to 10%), but are also seen commonly in follicular adenomas. Correlation with morphologic and clinical findings is thus required. Follicular thyroid neoplasms with RAS mutations may behave more aggressively than those without. The assay tests for mutations in codon 12 and 13 (exon 1) and codon 61 (exon 2) in HRAS, KRAS and NRAS by a DNA-based sequencing method, with an approximate sensitivity of 1 to 5% mutation-bearing cells in a mixed sample. This assay will not detect RAS mutations outside the codons listed above.

Alternative Name(s)

KRAS,HRAS,NRAS,RAS Pyrosequencing

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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RAS Mutation Analysis, Thyroid Cancer
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