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Test Name

BRAF Mutation Analysis, Papillary Thyroid Cancer

CPT Code(s)

81210

Methodology

Real-Time Polymerase Chain Reaction (RT-PCR)

Reference Range(s)

Not detected

Clinical Significance

BRAF V600E mutations are found in 40-50% of papillary thyroid carcinoma (PTC), and much less commonly in anaplastic thyroid carcinoma or poorly differentiated carcinomas involving the thyroid. Correlation with morphologic and clinical findings is thus required. Cases of PTC with BRAF V600E mutation may be associated with more aggressive tumor characteristics and higher rates of recurrence and treatment failure. The assay tests for codons 600 and 601 BRAF mutations using a DNA-based mutation-specific PCR method, with an approximate sensitivity of 0.1% mutation-bearing cells in a mixed sample. BRAF mutations outside of these codons will not be detected.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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BRAF Mutation Analysis, Papillary Thyroid Cancer
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