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Test Name

PAX8/PPAR[gamma] Translocation, Thyroid Cancer

CPT Code(s)

81401

Methodology

Real-Time Polymerase Chain Reaction (PCR)

Reference Range(s)

Not detected

Clinical Significance

PAX8/PPARG translocation is associated with 25-50% of follicular thyroid carcinoma but has also been reported at low frequency in follicular adenomas. Correlation with morphologic and clinical findings is thus required. This assay detects elevated levels of PPARG transcripts, compared to a control gene, associated with PAX8/PPARG translocations by an RNA-based real-time quantitative reverse transcription PCR-based method. The lower limit of sensitivity is approximately 2.5% mutation-bearing cells in a mixed sample, but can vary due to RNA preservation and differing PPARG expression levels in any given neoplasm.

Alternative Name(s)

Follicular Thyroid Cancer

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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PAX8/PPAR[gamma] Translocation, Thyroid Cancer
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