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Test Name

RET/PTC Rearrangement, Thyroid Cancer

CPT Code(s)

81404

Includes

RETPTC1, RETPTC3

Methodology

Real-Time Polymerase Chain Reaction (PCR)

Reference Range(s)

RETPTC1 Not detected
RETPTC3 Not detected

Clinical Significance

RET/PTC gene fusion is detected in 5-40% of papillary thyroid carcinomas, but has been reported at low frequency in other types of thyroid lesions. Correlation with morphologic and clinical findings is thus required. The assay tests for both RET/PTC1 and RET/PTC3 rearrangements using a reverse transcription PCR assay. The lower limit of sensitivity is approximately 2.5% mutation-bearing cells in a mixed sample, but can vary due to RNA preservation.

Alternative Name(s)

Papillary Thyroid Cancer

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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RET/PTC Rearrangement, Thyroid Cancer
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