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Test Name

Thyroid Cancer Mutation Panel (BRAF, RAS, RET/PTC, PAX8/PPAR)

CPT Code(s)

81445

Includes

BRAF Mutation Analysis, Papillary Thyroid Cancer; RAS Mutation Analysis, Thyroid Cancer; RET/PTC Rearrangement, Thyroid Cancer; PAX8/PPAR[gamma] Translocation, Thyroid Cancer

Methodology

See individual tests

Reference Range(s)

BRAF Mutation Analysis, Papillary Thyroid Cancer

BRAF Mutation Not detected

RAS Mutation Analysis, Thyroid Cancer

HRAS Mutation Not detected
KRAS Mutation Not detected
NRAS Mutation Not detected

RET/PTC Rearrangement, Thyroid Cancer
RETPTC1 Not detected
RETPTC3 Not detected

PAX8/PPAR[gamma] Translocation, Thyroid Cancer

PAX8/PPAR gamma Not detected

Clinical Significance

The thyroid mutation panel assesses for all 8 of the most common mutations or rearrangements associated with thyroid neoplasia.

The BRAF codon 600 mutation, and RET/PTC1 and RET/PTC3 rearrangements are highly associated with papillary thyroid cancer, the PAX8-PPAR{gamma} with follicular carcinomas and RAS mutations (in either HRAS, KRAS and NRAS) usually with follicular neoplasms.

See test codes 90477 (BRAF), 90473 (RET/PTC), 90474 (PPAR/PAX8), and 90479 (RAS panel) for individual components.

A thyroid cytology diagnosis code with reflex to molecular, as appropriate, is also available.

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

90469
90469
90469
90469
90469
90469X
90469
90469
90469
90469X
90469
90469
90469
90469
90469
90469
90469
90469X
90469
90469
Thyroid Cancer Mutation Panel (BRAF, RAS, RET/PTC, PAX8/PPAR)
90469