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Test Name

Gliadin (Deamidated Peptide) Antibody (IgG, IgA)

CPT Code(s)

83516 (x2)

Methodology

Immunoassay (IA)

Reference Range(s)

Gliadin Antibody (IgG)

<20 Units Antibody not detected
≥20 Units Antibody detected

Gliadin Antibody (IgA)
<20 Units Antibody not detected
≥20 Units Antibody detected

Clinical Significance

Detection of antibodies to gliadin, one of the major protein components of gluten, is a sensitive assay useful in diagnosing celiac disease. However, gliadin antibodies may be found in individuals without celiac disease; thus gliadin antibody assays are less specific than assays measuring antibodies to endomysium and transglutaminase. Recent work has revealed that gliadin-reactive antibodies from celiac patients bind to a very limited number of specific epitopes on the gliadin molecule. Further, deamidation of gliadin results in enhanced binding of gliadin antibodies. Based on this information, assays using deamidated gliadin peptides bearing the celiac-specific epitopes have much higher diagnostic accuracy for celiac disease when compared to standard gliadin antibody assays.

Alternative Name(s)

Antigliadin Ab (IgA, IgG),Deamidated Gliadin (IgA, IgG),Anti-Gliadin Ab (IgA, IgG),Gliadin (IgA, IgG),DGP (IgA, IgG)

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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8889
8889
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35022
8889
8889
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3517N
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Gliadin (Deamidated Peptide) Antibody (IgG, IgA)
8889