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Test Name

Carnitine, LC/MS/MS

CPT Code(s)

82379

Includes

Carnitine, Total; Carnitine, Free; Carnitine, Esters; Esterified/Free Ratio

Methodology

Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Reference Range(s)

Carnitine, Total
Adult Male 30-70 µmol/L
Adult Female 25-58 µmol/L
Male ≤17 Years 32-62 µmol/L
Female ≤17 Years 28-59 µmol/L
Carnitine, Free
Adult Male 23-59 µmol/L
Adult Female 19-48 µmol/L
Male ≤17 Years 25-54 µmol/L
Female ≤17 Years 19-51 µmol/L
Carnitine, Esters
Adult Male 4-15 µmol/L
Adult Female 4-13 µmol/L
Male ≤17 Years 4-12 µmol/L
Female ≤17 Years 3-16 µmol/L
Esterified/Free Ratio
Adult Male  0.12-0.39
Adult Female  0.13-0.42
Male ≤17 Years  0.09-0.35
Female ≤17 Years 0.09-0.49

Clinical Significance

Serum carnitine analysis is useful in the diagnosis and monitoring of patients with carnitine deficiency (either primary or secondary). Primary carnitine deficiency is an autosomal recessively inherited genetic condition that affects carnitine uptake by cells and tissues through a defect in the plasma membrane carnitine transporter. Secondary carnitine deficiency can be seen in some disease states or in patients on carnitine-poor diets, but is also seen in a number of metabolic disorders. In these disorders, carnitine complexes with the accumulated substrate of the blocked metabolic step, and the resulting acylcarnitine ester is excreted in the urine, leading to a depletion of carnitine in the patient.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

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Carnitine, LC/MS/MS
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