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Test Name

Metanephrines, Fractionated, 24-Hour Urine

CPT Code(s)



Normetanephrine, Metanephrine, Total Metanephrines (calculated)


High Performance Liquid Chromatography (HPLC)

Reference Range(s)

3-8 Years 9-86 mcg/24 h
9-12 Years 26-156 mcg/24 h
13-17 Years 31-156 mcg/24 h
>17 Years Male 26-230 mcg/24 h
>17 Years Female 19-140 mcg/24 h
 3-8 Years 20-186 mcg/24 h
 9-12 Years 10-319 mcg/24 h
 13-17 Years 71-395 mcg/24 h
>17 Years Male 44-540 mcg/24 h
>17 Years Female 52-310 mcg/24 h
Total Metanephrines 
 3-8 Years 47-260 mcg/24 h
 9-12 Years 72-410 mcg/24 h
 13-17 Years 130-520 mcg/24 h
>17 Years Male 90-690 mcg/24 h
>17 Years Female 95-475 mcg/24 h

Clinical Significance

Diagnosis and follow up of patients with pheochromocytoma and related neurogenic tumors.
Drugs which can interfere with testing due to physiologic response: bromocriptine, bronchodilators, clonidine, digoxin, L-dopa, labetelol, methyldopa, monoamine oxidase inhibitors, nitroglycerin, reserprine, sympathomimetic amines, tricyclic antidepressants.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

Metanephrines, Fractionated, 24-Hour Urine