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Test Name

Myelin Oligodendrocyte Glycoprotein(MOG)Antibody with Reflex to Titer,CSF

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CPT Code(s)**

86255
**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.

Includes

If the MOG Antibody screen is positive, then a semi-quantitative titer will be performed at an additional charge (CPT code(s): 86256).

Methodology

Cell-based Immunofluorescence Assay

Reference Range(s)

MOG Ab CBA, CSF Negative
  MOG Ab Titer, CSF <1:2 titer

Clinical Significance

Neuromyelitis optica (NMO) is an inflammatory disorder predominantly affecting the optic nerves and spinal cord. Limited forms of disease including isolated optic neuritis, brainstem encephalitis and longitudinal extensive transverse myelitis (LETM) or acute disseminated encephalomyelitis (ADEM) have been referred to as NMO spectrum disorder (NMOSD). The majority of individuals with NMO and many with NMOSD have antibodies against aquaporin 4 (AQP4). MOG antibodies have been reported without AQP4 antibodies in individuals with NMO and other non-multiple sclerosis demyelinating diseases. The presence of MOG antibodies in AQP4 antibody negative individuals can help differentiate between multiple sclerosis (MS) and non-MS demyelinating diseases and aid in clinical management decisions.

Alternative Name(s)

Transverse Myelitis Antibody,NMO Spectrum Disorder,Myelin oligodendrocyte glycoprotein,MOG-IgG,LETM antibody,Optic Neuritis Antibody,ADEM antibody,NMOSD

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Myelin Oligodendrocyte Glycoprotein(MOG)Antibody with Reflex to Titer,CSF
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