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Test Name

ANCA Vasculitides

CPT Code(s)

86021 (x2)

Includes

Myeloperoxidase Antibody, Proteinase-3 Antibody

Methodology

Immunoassay (IA)

Reference Range(s)

Myeloperoxidase Antibody

<1.0 AI No antibody detected
≥1.0 AI Antibody detected
Proteinase-3 Antibody
<1.0 AI No antibody detected
≥1.0 AI Antibody detected

Clinical Significance

Testing for anti-neutrophil cytoplasmic antibodies (P-ANCA and/or C-ANCA) has been found to be useful in establishing the diagnosis of suspected vascular diseases (e.g., crescentic glomerulonephritis, microscopic polyarteritis and Churg-Strauss syndrome), bowel disease (Crohn's Disease, ulcerative colitis, primary sclerosing cholangitis, and autoimmune hepatitis) as well as with other autoimmune diseases (drug-induced lupus, SLE, Felty's syndrome).
ANCA has classically been divided into C-ANCA and P-ANCA depending on the immunofluorescent pattern observed. More recently the specific antigens responsible for these patterns have been described and isolated. The antigen that gives the C-ANCA pattern is proteinase-3 (PR-3). Multiple antigens are responsible for P-ANCA pattern, the principle antigen being myeloperoxidase (MPO).
Patients with vascular diseases will generally have either a C-ANCA pattern or P-ANCA pattern, and give positive results in specific tests for PR-3 or MPO.
Patients with bowel disease have been shown to have antibodies that give a P-ANCA or C-ANCA pattern. These antibodies however, may not be directed towards MPO.
Patients with drug induced lupus, etc., often present with a P-ANCA pattern that is associated with antibodies against MPO.

Alternative Name(s)

Neutrophil Cytoplasmic Antibodies,ANCA Panel for Vasculitis, Serum,ANCA

To view specimen requirements and codes please Select a regional laboratory.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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4044F
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4044N
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1391
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136733
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ANCA Vasculitides
36733