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Test Name

Oncomine™ Dx Target Test (New)

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

CPT Code(s)**

0022U
**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.

Methodology

Next Generation Sequencing

Reference Range(s)

See Laboratory Report

Clinical Significance

The Oncomine™ Dx Target Test is a qualitative in vitro diagnostic test that uses targeted high throughput, parallel sequencing technology to detect single nucleotide variants (SNVs), deletions in 23 genes from DNA, and fusions in ROS1 from RNA. Specimen extracts are isolated from formalin-fixed, paraffin-embedded (FFPE) tumor tissue samples from patients with non-small cell lung cancer (NSCLC) and analyzed using the Ion PGM™ Dx System. These genes are well characterized in the published literature and associated with oncology drugs that are FDA approved, part of National Comprehensive Cancer Network (NCCN) guidelines, or in clinical trials.

The test is indicated to aid in selecting non-small cell lung cancer (NSCLC) patients for targeted therapies as seen below-
BRAF V600E mutation: TAFINLAR® (dabrafenib) in combination with MEKINIST® (trametinib)
ROS1 fusion: XALKORI® (crizotinib)
EGFR L858R mutation and Exon 19 deletions: IRESSA® (gelfitinib)

Alternative Name(s)

MEKINIST,ROS1 fusion,Gefitinib,XALKORI,Cancer Companion Dx,Lung cancer companion Dx,Companion Diagnostics,NSCLC,Non small cell lung cancer,Crizotinib,Trametinib,Companion Dx,EGFR,NGS lung cancer,TAFINLAR,Dabrafenib,IRESSA,BRAF

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Oncomine™ Dx Target Test
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