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Test Name

Herpes Simplex Virus 1 (IgG), Type-Specific Antibody

CPT Code(s)

86695

Methodology

Immunoassay (IA)

Limitations

Individuals infected with HSV may not exhibit detectable IgG antibody in the early stages of infection.

Reference Range(s)

Index Interpretation
<0.90 Negative
0.90-1.09 Equivocal
>1.09 Positive
This assay utilizes recombinant type-specific antigens to differentiate HSV-1 from HSV-2 infections. A index positive result cannot distinguish between recent and past infection. If recent HSV infection is suspected but the results are negative or equivocal, the assay should be repeated in 4-6 weeks. The performance index characteristics of the assay have not been established for pediatric populations, immunocompromised patients, or neonatal screening.

Clinical Significance

Herpes Simplex Virus (HSV) is responsible for several clinically significant human viral diseases, with severity ranging from inapparent to fatal. Clinical manifestations include genital tract infections, neonatal herpes, meningoencephalitis, keratoconjunctivitis, and gingivostomatitis. There are two HSV serotypes that are closely related antigenically. HSV type 2 is more commonly associated with genital tract and neonatal infections, while HSV type 1 is more commonly associated with infections of non-genital sites. Specific typing is not usually required for diagnosis or treatment. The mean time to seroconversion using the type specific assay is 25 days. The performance of this assay has not been established for use in a pediatric population, for neonatal screening, or for testing of immunocompromised patients.

To view specimen requirements and codes please Select a regional laboratory.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

3636
3636
3636
3636
3636
3636F
3636F
3636
3636
3636F
3636X
3636
3636 HSV1 G
3636 NTC
HERPES 1 G
HSV 1 G TYPE
HSV1 G SPEC
HSV1 IgG
3636
3636
3636
3636
3636
3636
3636X
103636
3636
3636
Herpes Simplex Virus 1 (IgG), Type-Specific Antibody
3636