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Test Name

Amino Acid Analysis, LC/MS, Urine

CPT Code(s)

82139, 82570

Includes

1-Methylhistidine, 3-Methylhistidine, Alanine, Alpha-Amino Adipic Acid, Alpha-Amino Butyric Acid, Arginine, Asparagine, Aspartic Acid, Beta Alanine, Beta-Amino Isobutyric Acid, Citrulline, Cystathionine, Cystine, Ethanolamine, Gamma-Amino Butyric Acid, Glutamic Acid, Glutamine, Glycine, Histidine, Homocystine, Hydroxylysine, Hydroxyproline, Isoleucine, Leucine, Lysine, Methionine, Ornithine, Phenylalanine, Proline, Sarcosine, Serine, Taurine, Threonine, Tryptophan, Tyrosine, Valine, Creatinine Random Urine

Methodology

Liquid Chromatography/Mass Spectrometry (LC/MS)

Reference Range(s)

  Age mmol/mol creat
Aspartic Acid ≤30 Days  ≤7
  31 Days-23 Months  ≤11
  2-17 Years  ≤2
  ≥18 Years  ≤2
     
Glutamic Acid ≤30 Days  4-19
  31 Days-23 Months  3-30
  2-17 Years  ≤10
  ≥18 Years  ≤3
     
Hydroxyproline ≤30 Days  30-485
  31 Days-23 Months  2-345
  2-17 Years  ≤4
  ≥18 Years  ≤2
     
Serine ≤30 Days  44-454
  31 Days-23 Months  39-422
  2-17 Years  13-127
  ≥18 Years  10-71
     
Asparagine ≤30 Days  8-42
  31 Days-23 Months  5-132
  2-17 Years  3-42
  ≥18 Years  2-37
     
Alpha-Amino Adipic Acid ≤30 Days  ≤10
  31 Days-23 Months  ≤36
  2-17 Years  ≤34
  ≥18 Years  ≤11
     
Glycine ≤30 Days   215-2053
  31 Days-23 Months  105-413
  2-17 Years  23-413
  ≥18 Years  ≤330
     
Glutamine ≤30 Days  ≤355
  31 Days-23 Months  41-396
  2-17 Years  18-188
  ≥18 Years  21-182
     
Sarcosine ≤30 Days  ≤18
  31 Days-23 Months  ≤19
  2-17 Years  ≤2
  ≥18 Years  ≤69
     
Beta Alanine  ≤30 Days  ≤9
  31 Days-23 Months  ≤15
  2-17 Years  ≤5
  ≥18 Years  ≤10
     
Taurine ≤30 Days  ≤650
  31 Days-23 Months  ≤670
  2-17 Years  ≤255
  ≥18 Years  ≤232
     
Histidine  ≤30 Days  40-301
  31 Days-23 Months  56-543
  2-17 Years  9-425
  ≥18 Years  17-266
     
Citrulline ≤30 Days  ≤4
  31 Days-23 Months  ≤13
  2-17 Years  ≤4
  ≥18 Years  ≤2
     
Arginine ≤30 Days  ≤30
  31 Days-23 Months  ≤35
  2-17 Years  ≤8
  ≥18 Years  ≤5
     
Threonine ≤30 Days  ≤112
  31 Days-23 Months  9-158
  2-17 Years  4-60
  ≥18 Years  4-46
     
Alanine  ≤30 Days  45-264
  31 Days-23 Months  16-294
  2-17 Years  8-156
  ≥18 Years  9-67
     
1-Methylhistidine  ≤30 Days  ≤16
  31 Days-23 Months  4-71
  2-17 Years  5-400
  ≥18 Years  ≤204
     
Gamma-Amino Butyric Acid  ≤30 Days

 ≤1

  31 Days-23 Months  ≤2
  2-17 Years  ≤2
  ≥18 Years  ≤2
     
3-Methylhistidine ≤30 Days  9-45
  31 Days-23 Months  14-35
  2-17 Years  11-40
  ≥18 Years  10-35
     
Beta-Amino Isobutyric Acid ≤30 Days  ≤269
  31 Days-23 Months  ≤309
  2-17 Years  ≤133
  ≥18 Years  ≤88
     
Proline  ≤30 Days  ≤219
  31 Days-23 Months  ≤216
  2-17 Years  ≤11
  ≥18 Years  ≤2
     
Ethanolamine  ≤30 Days  87-490
  31 Days-23 Months  54-176
  2-17 Years  27-114
  ≥18 Years  21-65
     
Alpha-Amino Butyric Acid  ≤30 Days  ≤7
  31 Days-23 Months  ≤7
  2-17 Years  ≤5
  ≥18 Years  ≤2
     
Tyrosine ≤30 Days  4-59
  31 Days-23 Months  10-69
  2-17 Years  3-48
  ≥18 Years  3-19
     
Valine  ≤30 Days  2-20
  31 Days-23 Months  4-21
  2-17 Years  2-20
  ≥18 Years  2-5
     
Methionine ≤30 Days  ≤7
  31 Days-23 Months  ≤7
  2-17 Years  ≤5
  ≥18 Years  ≤2
     
Cystathionine  ≤30 Days  2-20
  31 Days-23 Months  ≤29
  2-17 Years  ≤8
  ≥18 Years  ≤9
     
Isoleucine ≤30 Days  ≤9
  31 Days-23 Months  ≤12
  2-17 Years  ≤5
  ≥18 Years  ≤3
     
Leucine ≤30 Days  ≤23
  31 Days-23 Months  ≤24
  2-17 Years  ≤13
  ≥18 Years  ≤6
     
Homocystine ≤30 Days  <1
  31 Days-23 Months  <4
  2-17 Years  <1
  ≥18 Years  <1
     
Phenylalanine  ≤30 Days  3-24
  31 Days-23 Months  6-39
  2-17 Years  2-22
  ≥18 Years  2-9
     
Tryptophan ≤30 Days  2-21
  31 Days-23 Months  5-46
  2-17 Years  2-27
  ≥18 Years  2-14
     
Ornithine ≤30 Days  ≤39
  31 Days-23 Months  ≤11
  2-17 Years  ≤5
  ≥18 Years  ≤4
     
Lysine ≤30 Days  13-284
  31 Days-23 Months  4-239
  2-17 Years  3-112
  ≥18 Years  3-59
     
Cystine ≤30 Days  15-48
  31 Days-23 Months  6-28
  2-17 Years  3-20
  ≥18 Years  3-13
     
Hydroxylysine ≤30 Days  5-117
  31 Days-23 Months  2-72
  2-17 Years  ≤8
  ≥18 Years  ≤8
Creatinine, Random Urine
0-6 Months 0.18-2.86 mmol/L
7-11 Months 0.18-3.19 mmol/L
1-2 Years 0.18-11.33 mmol/L
3-8 Years 0.18-13.19 mmol/L
9-12 Years 0.18-16.19 mmol/L
Adult 2.38-26.55 mmol/L

Clinical Significance

Amino acid analysis is necessary for the diagnosis of a variety of inborn errors of metabolism. These include, but are not limited to, phenylketonuria, tyrosinemia, citrullinemia, non-ketotic hyperglycinemia, maple syrup urine disease, and homocystinuria. The assay is also key for the continued monitoring of treatment plans for these disorders and useful for assessing nutritional status of patients. Our methodology is highly accurate at very low levels as well as at elevated levels

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Amino Acid Analysis, LC/MS, Urine
36183