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Test Name

Insulin Autoantibody

CPT Code(s)

86337

Methodology

Radiobinding Assay (RBA)

Limitations

In diabetic children <14 years of age (identified by urine screening), the frequency of insulin antibodies (IAA) and islet cell antibodies (ICA) are 43-56% and 84%, respectively; the frequency of both is 40%, and the frequency of one or both is 88%.4 In the same study, cohorts using ICA, GAD-65 antibodies and IAA, sensitivities and specificities are 93% and 93% for any positive, respectively, and 39% and >99%, respectively, for all positives. IAA are found at onset of diabetes in only 4% of adults, but are universally present in diabetic children <4 years old at onset. The predictive value of both tests (ICA and IAA) is 60-77% in first-degree relatives of patients with IDDM for the development of IDDM in 5-10 years.

Reference Range(s)

 <0.4 U/mL

Alternative Name(s)

Human Insulin Antibody

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

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Insulin Autoantibody
36178