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Test Name

Calcium, Ionized

CPT Code(s)

82330

Methodology

Ion Specific Electrode (ISE)

Reference Range(s)

<8 Months  Not established
8 Months-10 Years 4.9-5.4 mg/dL
11-17 Years 4.8-5.3 mg/dL
Adult 4.8-5.6 mg/dL

Clinical Significance

The ionized calcium is determined by an ion selective electrode methodology. The result that is generated is pH adjusted. The result is empirically based on a measured pH and ionized calcium concentration normalized to a pH of 7.40. This calculation compensates for in vitro changes in pH due to loss of CO2 through specimen handling. Ionized calcium represents the true "bioavailable" calcium in the circulation. In situations where the total calcium is normal but does not fit the clinical picture, e.g., hyperparathyroidism, a determination of the ionized calcium will, many times, show an elevation in the "bioavailable" calcium component. This may be due to alterations in protein concentrations, especially albumin, that binds most of the calcium in the circulation.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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42050
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4831
306
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306
306
19950E
306X
19950E
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Calcium, Ionized
306