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Test Name

Celiac Disease Comprehensive Panel

CPT Code(s)

83516, 82784

Includes

Tissue Transglutaminase, IgA with Reflexes; Total IgA with Reflex

If the Tissue Transglutaminase IgA is positive, Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255). If the Endomysial Antibody Screen (IgA) is positive, Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256).
If the Total IgA is less than the lower limit of the reference range, based on age, Tissue Transglutaminase IgG will be performed at an additional charge (CPT code(s): 83516).

Methodology

Immunoassay (IA) • Immunoturbidimetric Assay

Reference Range(s)

(tTG) Antibody, (IgA)

<4 U/mL No antibody detected
≥4 U/mL Antibody detected

IgA, Serum
Cord Blood 1-3 mg/dL
1 Month 2-43 mg/dL
2-5 Months 3-66 mg/dL
6-9 Months 7-66 mg/dL
10-12 Months 12-75 mg/dL
1-3 Years 24-121 mg/dL
4-6 Years 33-235 mg/dL
7-9 Years 41-368 mg/dL
10-11 Years 64-246 mg/dL
12-13 Years 70-432 mg/dL
14-15 Years 57-300 mg/dL
≥16 Years 81-463 mg/dL

Clinical Significance

Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy.
Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance.
The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Celiac Disease Comprehensive Panel
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