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ANA Multiplex with Reflex to 11 Antibody Cascade
To view specimen requirements and codes please Select a regional laboratory.Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)
**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.
ANA Multiplex with Reflex to 11 Antibody Cascade begins with an ANAchoice® Screen.
If the ANAchoice® Screen is positive, it will reflex the following five antibodies at an additional charge: dsDNA (CPT code(s): 86225), Sm/RNP (CPT code(s): 86235), RNP (CPT code(s): 86235), Sm (CPT code(s): 86235), and Chromatin (CPT code(s): 86235).
If any of those five antibodies are positive, the cascade stops and the results are reported.
If all five of those antibodies are negative, four additional antibodies will be reflexed at an additional charge: SSA (CPT code(s): 86235), SSB (CPT code(s): 86235), Scl-70 (CPT code(s): 86235), Jo-1 (CPT code(s): 86235).
If any of those four antibodies are positive, the cascade stops and the results are reported.
If all four of those antibodies are negative, the following two additional antibodies will be reflexed at an additional charge: Ribosomal P (CPT code(s): 83516) and Centromere B (CPT code(s): 86235).
The cascade stops upon the first positive antibody found in a group. It is possible that antibodies in subsequent groups are also positive, but will not be added or reported. Please contact your local Quest Diagnostics Laboratory if you are interested in adding this additional testing.
The ANAchoice® Cascading Reflex provides physicians with a cost-effective and medically justified approach to evaluating a patient with suspected rheumatologic disease. Eleven antibodies associated with specific rheumatologic disease entities are analyzed and resulted in sequential tiers until positive findings are reported. The test is not intended for the work-up of autoimmune hepatitis or other non-rheumatologic diseases.
Progressive ANA,Multiplex Cascade
Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.
The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.
* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.