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Test Name

HLA-B*5701 Typing

CPT Code(s)

81381

Includes

Additional testing by Sequence Based Typing (SBT) may be performed when necessary.

Methodology

Polymerase Chain Reaction (PCR) • Sequence Specific Oligonucleotide Probes (SSO)

Limitations

A negative result does not rule out the risk for ABC HSR and clinical vigilance should be maintained regardless of the result. The frequency of HLA/-B5701 is approximately 8% in Caucasians and 2% in African Americans.

Reference Range(s)

See Laboratory Report

Clinical Significance

Abacavir therapy for HIV treatment is associated with significant drug hypersensitivity in approximately 8% of recipients, with retrospective studies indicating a strong association with the HLA-B*5701 allele. HLA-B*5701 typing can be used for genetic risk stratification prior to initiation of abacavir therapy.

To view specimen requirements and codes please Select a regional laboratory.

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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HLA-B*5701 Typing
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