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Test Name

Colorectal Cancer Mutation Panel (KRAS, PIK3CA, BRAF, NRAS)

CPT Code(s)

81275, 81276, 81210, 81404, 81311

Includes

KRAS Mutation Analysis, PIK3CA Mutation Analysis, BRAF Mutation Analysis, NRAS Mutation Analysis

Methodology

Polymerase Chain Reaction (PCR) • Sequencing

Reference Range(s)

KRAS Mutation Analysis Not detected
PIK3CA Mutation Analysis Not detected
BRAF Mutation Analysis Not detected
NRAS Mutation Analysis Not detected

Clinical Significance

This panel detecting tumor-associated somatic mutations in 4 different oncogenes can predict response to EGFR-targeted immunotherapy in patients with metastatic colorectal cancer. Tumors with mutations in KRAS, NRAS, BRAF and PI3KCA (exons 9 and 20) are associated with inferior response to anti-EGFR immunotherapy, and variably associated with more aggressive clinical behavior compared to unmutated cases.

Test FAQ

PIK3CA Mutation Analysis

To view specimen requirements and codes please Select a regional laboratory.

Not sure which laboratory serves your office? Call us 866-MYQUEST (866-697-8378)

Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.

* The tests listed by specialist are a select group of tests offered. For a complete list of Quest Diagnostics tests, please refer to our Directory of Services.

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Colorectal Cancer Mutation Panel (KRAS, PIK3CA, BRAF, NRAS)
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