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HIV-1 Integrase Genotype
Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) • Sequencing
See Laboratory Report
The emergence of integrase drug resistance mutations has been observed in vitro and in patients experiencing virologic failure on raltegravir in clinical trials. Twenty three percent of patients receiving raltegravir in a clinical trial experienced virologic failure at 48 weeks and genotypic analysis detected raltegravir associated resistance mutations in 68% of viroligic failures. This assay amplifies and sequences the HIV-1 integrase gene and reports mutations at positions associated with integrase inhibitor drug resistance.
Isentress (Raltegravir, MK-0518) Resistance,HIV-1 Integrase Strand Transfer Inhibitor,Raltegravir,Elvitegravir,HIV-1 Integrase Mutations,MK-0518
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