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Test Name

NPM (Exon 12) Mutation Analysis, Cell-based

CPT Code(s)

81310

Methodology

Fragment Analysis

Reference Range(s)

Negative

Clinical Significance

Acute Myeloid Leukemia (AML) is a clinically heterogeneous disease. Recurrent cytogenetic abnormalities help define subgroups with different prognosis and identify patients whom might benefit from targeted therapies. However, almost half adults AML cases display a normal karyotype by conventional cytogenetics, and the clinical and molecular features of this large subgroup of patients are poorly understood. The NPM exon 12 mutation can serve as predictor in AML cases with a normal karyotype, good response to induction chemotherapy and as a marker for monitoring of minimal residual disease. NPM exon 12 mutations are AML-specific since they are not detected in normal cells or other neoplasms.

Alternative Name(s)

Nucleophosmin,Acute Myeloid Leukemia (AML)

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Reference ranges are provided as general guidance only. To interpret test results use the reference range in the laboratory report.

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NPM (Exon 12) Mutation Analysis, Cell-based
16158