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ABL Kinase Domain Mutation in CML, Cell-based
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**IMPORTANT: CPT Code is informational only; obtain the Test Code for ordering.
Nested Polymerase Chain Reaction • Real-Time Polymerase Chain Reaction (RT-PCR) • Sequencing
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Imatinib mesylate (ST1571;Gleevec) is a selective BCR-ABL kinase inhibitor, effective in the treatment of chronic myelogenous leukemia (CML). Most patients in chronic phase maintain durable responses; however, many in blast crisis fail to respond, or relapse quickly. ABL kinase domain mutations are the most commonly identified mechanism associated with relapse. The molecular monitoring in the first few months of therapy may play a crucial role in detecting patients at high risk of Imatinib resistance. This ABL kinase mutation assay may detect drug-resistant mutations before clinical relapse and identify candidate suitable for alternative therapy.
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